Hitchhiking fads en route to peroxisomes
نویسنده
چکیده
A unique aspect of protein translocation across the peroxisomal membrane is that folded and oligomeric proteins get across this membrane (Purdue and Lazarow, 2001). The generality of this rule, its specific features, and its mechanism are not fully understood. A paper in this issue addresses, in a very thorough fashion, the assembly, cofactor binding, and import of an oligomeric protein, acyl-CoA oxidase (Aox), into the peroxisome matrix (Titorenko et al., 2002, this issue).
منابع مشابه
Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA
Eukaryotic cells use microtubule-based intracellular transport for the delivery of many subcellular cargos, including organelles. The canonical view of organelle transport is that organelles directly recruit molecular motors via cargo-specific adaptors. In contrast with this view, we show here that peroxisomes move by hitchhiking on early endosomes, an organelle that directly recruits the trans...
متن کاملContribution of the Endoplasmic Reticulum to Peroxisome Formation
How peroxisomes are formed in eukaryotic cells is unknown but important for insight into a variety of diseases. Both human and yeast cells lacking peroxisomes due to mutations in PEX3 or PEX19 genes regenerate the organelles upon reintroduction of the corresponding wild-type version. To evaluate how and from where new peroxisomes are formed, we followed the trafficking route of newly made YFP-t...
متن کاملInhibitors of Copi and Copii Do Not Block PEX3-Mediated Peroxisome Synthesis
In humans, defects in peroxisome biogenesis are the cause of lethal diseases typified by Zellweger syndrome. Here, we show that inactivating mutations in human PEX3 cause Zellweger syndrome, abrogate peroxisome membrane synthesis, and result in reduced abundance of peroxisomal membrane proteins (PMPs) and/or mislocalization of PMPs to the mitochondria. Previous studies have suggested that PEX3 ...
متن کاملSolving the dynamic traveling salesman problem using a genetic algorithm with trajectory prediction: An application to fish aggregating devices
The paper addresses the synergies from combining a heuristic method with a predictive technique to solve the Dynamic Traveling Salesman Problem (DTSP). Particularly, we build a genetic algorithm that feeds on Newton's motion equation to show how route optimization can be improved when targets are constantly moving. Our empirical evidence stems from the recovery of fish aggregating devices (FADs...
متن کاملPeroxisome biogenesis: Back to the endoplasmic reticulum?
Proteins are targeted to the membrane and matrix of peroxisomes by distinct pathways. Recent observations suggest a further route: a subset of peroxisomal membrane proteins might be targeted first to the endoplasmic reticulum, and from there to peroxisomes by vesicle-mediated transport.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of Cell Biology
دوره 156 شماره
صفحات -
تاریخ انتشار 2002